Blar i Bergen Open Research Archive på forfatter "Rigg, Emma Kayleigh"
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CCT196969 effectively inhibits growth and survival of melanoma brain metastasis cells
Reigstad, Agathe; Herdlevær, Christina Frantzen; Rigg, Emma Kayleigh; Hoang, Tuyen; Bjørnstad, Ole Vidhammer; Aasen, Synnøve Nymark; Preis, Jasmin; Haan, Claude; Sundstrøm, Terje; Thorsen, Frits (Journal article; Peer reviewed, 2022)Melanomas frequently metastasize to the brain. Despite recent progress in the treatment of melanoma brain metastasis, therapy resistance and relapse of disease remain unsolved challenges. CCT196969 is a SRC family kinase ... -
Inhibition of extracellular vesicle-derived miR-146a-5p decreases progression of melanoma brain metastasis via Notch pathway dysregulation in astrocytes
Rigg, Emma Kayleigh; Wang, Jiwei; Xue, Zhiwei; Lunavat, Taral; Liu, Guowei; Hoang, Tuyen; Parajuli, Himalaya; Han, Mingzhi; Bjerkvig, Rolf; Nazarov, Petr V.; Nicot, Nathalie; Kreis, Stephanie; Margue, Christiane; Nomigni, Miléne Tetsi; Utikal, Jochen; Miletic, Hrvoje; Sundstrøm, Terje; Ystaas, Lars Andreas Rømo; Li, Xingang; Thorsen, Frits (Journal article; Peer reviewed, 2023)Melanoma has the highest propensity of all cancers to metastasize to the brain with a large percentage of late-stage patients developing metastases in the central nervous system (CNS). It is well known that metastasis ...